Tumor vessel co-option probed by single-cell analysis

Tumor vessel co-option probed by single-cell analysis

Summary: Tumor vessel co-option is poorly understood, yet it is a resistance mechanism against anti-angiogenic therapy (AAT). The heterogeneity of co-opted endothelial cells (ECs) and pericytes, co-opting cancer and myeloid cells in tumors growing via vessel co-option, has not been investigated at t...

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Main Authors: Laure-Anne Teuwen, Laura P.M.H. De Rooij, Anne Cuypers, Katerina Rohlenova, Sébastien J. Dumas, Melissa García-Caballero, Elda Meta, Jacob Amersfoort, Federico Taverna, Lisa M. Becker, Nuphar Veiga, Anna Rita Cantelmo, Vincent Geldhof, Nadine V. Conchinha, Joanna Kalucka, Lucas Treps, Lena-Christin Conradi, Shawez Khan, Tobias K. Karakach, Stefaan Soenen, Stefan Vinckier, Luc Schoonjans, Guy Eelen, Steven Van Laere, Mieke Dewerchin, Luc Dirix, Massimiliano Mazzone, Yonglun Luo, Peter Vermeulen, Peter Carmeliet
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports
Subjects:
tumor vessel co-option
tumor angiogenesis
anti-angiogenic therapy
metastasis
resistance
single-cell RNA sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721006185

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