Activation of Cannabinoid Receptor Type II by AM1241 Ameliorates Myocardial Fibrosis via Nrf2-Mediated Inhibition of TGF-β1/Smad3 Pathway in Myocardial Infarction Mice

Activation of Cannabinoid Receptor Type II by AM1241 Ameliorates Myocardial Fibrosis via Nrf2-Mediated Inhibition of TGF-β1/Smad3 Pathway in Myocardial Infarction Mice

Aims: Myocardial interstitial fibrosis is a major histologic landmark resulting in cardiac dysfunction after myocardial infarction (MI). Activation of cannabinoid receptor type II (CB2 receptor) have been demonstrated to reduce fibrosis in hepatic cirrhotic rat. However, the anti-fibrotic effect of...

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Bibliographic Details
Main Authors: Xiang Li, Dong Han, Zuhong Tian, Beilei Gao, Miaomiao Fan, Congye Li, Xiujuan Li, Yabin Wang, Sai Ma, Feng Cao
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Cannabinoid receptor II
Myocardial Infarction
Fibrosis
Nrf2
TGF-β1
Smad3
Online Access:http://www.karger.com/Article/FullText/447855

Internet

http://www.karger.com/Article/FullText/447855

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