Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig

Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig

Abstract Novel biologics that redirect cytotoxic T lymphocytes (CTLs) to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL toward tumor associated antigens (TAA) expressed on tumor cells remains a chall...

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Bibliographic Details
Main Authors: Philip D. Bardwell, Matthew M. Staron, Junjian Liu, Qingfeng Tao, Susanne Scesney, Gail Bukofzer, Luis E. Rodriguez, Chee-Ho Choi, Jennifer Wang, Qing Chang, Feng Dong, Cherrie Donawho, Jieyi Wang, Christine M. Grinnell, Edit Tarcsa, Charles Hutchins, Tariq Ghayur, Jijie Gu
Format: Article
Language:English
Published: SpringerOpen 2017-06-01
Series:Protein & Cell
Subjects:
DVD-Ig
Half DVD-Ig
Halfbody
epidermal growth factor receptor
redirected T-cell cytotoxicity
rCTL
Online Access:http://link.springer.com/article/10.1007/s13238-017-0429-z

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http://link.springer.com/article/10.1007/s13238-017-0429-z

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