Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line

Chronic inflammation is associated with cancer. CXCL8 promotes tumor microenvironment construction through recruiting leukocytes and endothelial progenitor cells that are involved in angiogenesis. It also enhances tumor cell proliferation and migration. Metformin, type II diabetes medication, demons...

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Bibliographic Details
Main Authors: Zhihui Xiao, Wenjun Wu, Vladimir Poltoratsky
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2017/6589423