(Sila)Difluoromethylation of Fluorenyllithium with CF3H and CF3TMS

(Sila)Difluoromethylation of Fluorenyllithium with CF3H and CF3TMS

Abstract Difluoromethylation of the C9-H site of the fluorene ring using lithium base and fluoroform (CF3H), which is one of the most cost-effective difluoromethylating reagents, is attained to give difluoromethylated fluorenes with an all-carbon quaternary center. The Ruppert–Prakash reagent (CF3TM...

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Bibliographic Details
Main Authors: Kenichi Maruyama, Daichi Saito, Koichi Mikami
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2018-07-01
Series:SynOpen
Subjects:
fluoroform
ruppert–prakash reagent
bioisostere
fluorene
difluoromethylation
difluoromethyl
difluoromethylene
difluorocarbene
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1610361

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1610361

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