A novel approach to oral apoA-I mimetic therapy[S]

A novel approach to oral apoA-I mimetic therapy[S]

Transgenic tomato plants were constructed with an empty vector (EV) or a vector expressing an apoA-I mimetic peptide, 6F. EV or 6F tomatoes were harvested, lyophilized, ground into powder, added to Western diet (WD) at 2.2% by weight, and fed to LDL receptor-null (LDLR−/−) mice at 45 mg/kg/day 6F. A...

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Bibliographic Details
Main Authors: Arnab Chattopadhyay, Mohamad Navab, Greg Hough, Feng Gao, David Meriwether, Victor Grijalva, James R. Springstead, Mayakonda N. Palgnachari, Ryan Namiri-Kalantari, Feng Su, Brian J. Van Lenten, Alan C. Wagner, G.M. Anantharamaiah, Robin Farias-Eisner, Srinivasa T. Reddy, Alan M. Fogelman
Format: Article
Language:English
Published: Elsevier 2013-04-01
Series:Journal of Lipid Research
Subjects:
6F peptide
apolipoprotein A-I mimetic peptides
atherosclerosis
lipoproteins
genetically engineered tomato plants
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520422047

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http://www.sciencedirect.com/science/article/pii/S0022227520422047

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