CD38 Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD+/Sirt1 Signaling Pathway

CD38 Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD+/Sirt1 Signaling Pathway

Our previous research showed that CD38 played vital roles in Ang-II induced hypertrophy and high fat diet induced heart injury. However, the role of CD38 in heart aging is still unknown. In the present study, we reported that CD38 knockdown significantly protected cardiomyocytes from D-galactose (D-...

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Bibliographic Details
Main Authors: Ling-Fang Wang, Qing Cao, Ke Wen, Yun-Fei Xiao, Ting-Tao Chen, Xiao-Hui Guan, Yu Liu, Li Zuo, Yi-Song Qian, Ke-Yu Deng, Hong-Bo Xin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Physiology
Subjects:
CD38
D-galactose
oxidative stress
heart senescence
NAD+
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01125/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01125/full

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