Initial In Vitro and In Vivo Evaluation of a Novel CCK2R Targeting Peptide Analog Labeled with Lutetium-177

Initial In Vitro and In Vivo Evaluation of a Novel CCK2R Targeting Peptide Analog Labeled with Lutetium-177

Targeting of cholecystokinin-2 receptor (CCK2R) expressing tumors using radiolabeled minigastrin (MG) analogs is hampered by rapid digestion of the linear peptide in vivo. In this study, a new MG analog stabilized against enzymatic degradation was investigated in preclinical studies to characterize...

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Bibliographic Details
Main Authors: Anton Amadeus Hörmann, Maximilian Klingler, Maliheh Rezaeianpour, Nikolas Hörmann, Ronald Gust, Soraya Shahhosseini, Elisabeth von Guggenberg
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
cholecystokinin-2 receptor
minigastrin
molecular imaging
targeted radiotherapy
lutetium-177
Online Access:https://www.mdpi.com/1420-3049/25/19/4585

Internet

https://www.mdpi.com/1420-3049/25/19/4585

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