Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells

Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells

Mechanisms leading to age-related reductions in bone formation and subsequent osteoporosis are still incompletely understood. We recently demonstrated that kynurenine (KYN), a tryptophan metabolite, accumulates in serum of aged mice and induces bone loss. Here, we report on novel mechanisms underlyi...

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Bibliographic Details
Main Authors: Ahmed M. Elmansi, Khaled A. Hussein, Sergio Mas Herrero, Sudharsan Periyasamy-Thandavan, Alexandra Aguilar-Pérez, Galina Kondrikova, Dmitry Kondrikov, Nada H. Eisa, Jessica L. Pierce, Helen Kaiser, Ke-Hong Ding, Aisha L. Walker, Xue Jiang, Wendy B. Bollag, Mohammed Elsalanty, Qing Zhong, Xing-ming Shi, Yun Su, Maribeth Johnson, Monte Hunter, Charles Reitman, Brian F. Volkman, Mark W. Hamrick, Carlos M. Isales, Sadanand Fulzele, Meghan E. McGee-Lawrence, William D. Hill
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Bone Reports
Subjects:
Kynurenine
AhR
CXCL12
Hdac3
miR-29b-1-5p
Online Access:http://www.sciencedirect.com/science/article/pii/S2352187220300309

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http://www.sciencedirect.com/science/article/pii/S2352187220300309

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