Development, evaluation and application of 3D QSAR Pharmacophore model in the discovery of potential human renin inhibitors

Development, evaluation and application of 3D QSAR Pharmacophore model in the discovery of potential human renin inhibitors

<p>Abstract</p> <p>Background</p> <p>Renin has become an attractive target in controlling hypertension because of the high specificity towards its only substrate, angiotensinogen. The conversion of angiotensinogen to angiotensin I is the first and rate-limiting step of...

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Bibliographic Details
Main Authors:	John Shalini, Thangapandian Sundarapandian, Arooj Mahreen, Hong Jong, Kim Kwang, Lee Keun
Format:	Article
Language:	English
Published:	BMC 2011-12-01
Series:	BMC Bioinformatics

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