Reduced tissue osmolarity increases TRPV4 expression and pro-inflammatory cytokines in intervertebral disc cells

Reduced tissue osmolarity increases TRPV4 expression and pro-inflammatory cytokines in intervertebral disc cells

The mechanical behaviour and cellular metabolism of intervertebral discs (IVDs) and articular cartilage are strongly influenced by their proteoglycan content and associated osmotic properties. This osmotic environment is a biophysical signal that changes with disease and may contribute to the elevat...

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Bibliographic Details
Main Authors: BA Walter, D Purmessur, A Moon, J Occhiogrosso, DM Laudier, AC Hecht, JC Iatridis
Format: Article
Language:English
Published: AO Research Institute Davos 2016-07-01
Series:European Cells & Materials
Subjects:
TRPV4
intervertebral disc
osmolarity
degeneration
mechanobiology
Online Access:http://www.ecmjournal.org/papers/vol032/pdf/v032a08.pdf

Internet

http://www.ecmjournal.org/papers/vol032/pdf/v032a08.pdf

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