Structural and Functional Brain Abnormalities in Mouse Models of Lafora Disease

Structural and Functional Brain Abnormalities in Mouse Models of Lafora Disease

Mutations in the <i>EPM2A</i> and <i>EPM2B</i> genes, encoding laforin and malin proteins respectively, are responsible for Lafora disease, a fatal form of progressive myoclonus epilepsy with autosomal recessive inheritance. Neuroimaging studies of patients with Lafora diseas...

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Bibliographic Details
Main Authors: Daniel F. Burgos, Lorena Cussó, Gentzane Sánchez-Elexpuru, Daniel Calle, Max Bautista Perpinyà, Manuel Desco, José M. Serratosa, Marina P. Sánchez
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
Lafora disease, mouse models, volumetry, brain metabolites, MRI, FDG PET, <sup>1</sup>H-HRMAS MRS
Online Access:https://www.mdpi.com/1422-0067/21/20/7771

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https://www.mdpi.com/1422-0067/21/20/7771

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