PrP<sup>Sc </sup>accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases
<p>Abstract</p> <p>Prion diseases are disorders of protein conformation in which PrP<sup>C</sup>, the normal cellular conformer, is converted to an abnormal, protease-resistant conformer rPrP<sup>Sc</sup>. Approximately 80% of rPrP<sup>Sc </sup>a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-01-01
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| Series: | Molecular Neurodegeneration |
| Online Access: | http://www.molecularneurodegeneration.com/content/5/1/6 |