First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers

First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers

Abstract Background 2-Hydroxybenzylamine (2-HOBA) is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles. It is currently being developed for use as a nutritional supplement to help maintain good health and protect against th...

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Bibliographic Details
Main Authors: Lisa M. Pitchford, John A. Rathmacher, John C. Fuller, J. Scott Daniels, Ryan D. Morrison, Wendall S. Akers, Naji N. Abumrad, Venkataraman Amarnath, Patricia M. Currey, L. Jackson Roberts, John A. Oates, Olivier Boutaud
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Pharmacology and Toxicology
Subjects:
Safety
Pharmacokinetics
Humans
Salicylamine
γ-Ketoaldehydes
Online Access:http://link.springer.com/article/10.1186/s40360-018-0281-7

Internet

http://link.springer.com/article/10.1186/s40360-018-0281-7

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