An NF-kappaB- and IKK-Independent Function of NEMO Prevents Hepatocarcinogenesis by Suppressing Compensatory Liver Regeneration

An NF-kappaB- and IKK-Independent Function of NEMO Prevents Hepatocarcinogenesis by Suppressing Compensatory Liver Regeneration

The I-κB-Kinase (IKK) complex represents a central signaling nexus in the TNF-dependent activation of the pro-inflammatory NF-κB pathway. However, recent studies suggested that the distinct IKK subunits (IKKα, IKKβ, and NEMO) might withhold additional NF-&#954...

Full description

Bibliographic Details
Main Authors: Christiane Koppe, Florian Reisinger, Karina Wehr, Mihael Vucur, Christian Trautwein, Frank Tacke, Mathias Heikenwalder, Tom Luedde
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cancers
Subjects:
hepatocarcinogenesis
cholestasis
IKK complex
NF-κB
NEMO
IKKα, IKKβ
Online Access:https://www.mdpi.com/2072-6694/11/7/999

Internet

https://www.mdpi.com/2072-6694/11/7/999

Similar Items