A Novel Glycoproteomics Workflow Reveals Dynamic O-GlcNAcylation of COPγ1 as a Candidate Regulator of Protein Trafficking

A Novel Glycoproteomics Workflow Reveals Dynamic O-GlcNAcylation of COPγ1 as a Candidate Regulator of Protein Trafficking

O-linked β-N-acetylglucosamine (O-GlcNAc) is an abundant and essential intracellular form of protein glycosylation in animals and plants. In humans, dysregulation of O-GlcNAcylation occurs in a wide range of diseases, including cancer, diabetes, and neurodegeneration. Since its discovery more than 3...

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Bibliographic Details
Main Authors: Nathan J. Cox, Peter M. Luo, Timothy J. Smith, Brittany J. Bisnett, Erik J. Soderblom, Michael Boyce
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Endocrinology
Subjects:
O-GlcNAc
glycoproteomics
SILAC
click chemistry
COPI vesicle trafficking
protein secretion
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00606/full

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https://www.frontiersin.org/article/10.3389/fendo.2018.00606/full

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