Depolymerization of Fucosylated Chondroitin Sulfate with a Modified Fenton-System and Anticoagulant Activity of the Resulting Fragments

Depolymerization of Fucosylated Chondroitin Sulfate with a Modified Fenton-System and Anticoagulant Activity of the Resulting Fragments

Fucosylated chondroitin sulfate (fCS) from sea cucumber Isostichopus badionotus (fCS-Ib) with a chondroitin sulfate type E (CSE) backbone and 2,4-O-sulfo fucose branches has shown excellent anticoagulant activity although has also show severe adverse effects. Depolymerization represents an effective...

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Bibliographic Details
Main Authors: Jun-hui Li, Shan Li, Zi-jian Zhi, Lu-feng Yan, Xing-qian Ye, Tian Ding, Lei Yan, Robert John Linhardt, Shi-guo Chen
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:Marine Drugs
Subjects:
sea cucumber
fucosylated chondroitin sulfate
free-radical depolymerization
anticoagulant activity
Online Access:http://www.mdpi.com/1660-3397/14/9/170

Internet

http://www.mdpi.com/1660-3397/14/9/170

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