Clonal evolution and therapeutic resistance in solid tumors

Clonal evolution and therapeutic resistance in solid tumors

Tumors frequently arise as a result of an acquired genomic instability and the subsequent evolution of neoplastic populations with variable genomes. A barrier to the study of the somatic genetics of human solid tumors in vivo is the presence of admixtures of non-neoplastic cells with normal genomes...

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Bibliographic Details
Main Authors: Elizabeth eLenkiewicz, Lisa eEvers, Tara eHolley, Christian eRuiz, Lukas eBubendorf, Aleksander eSekulic, Ramesh K Ramanathan, Daniel D Von Hoff, Michael T Barrett
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-01-01
Series:Frontiers in Pharmacology
Subjects:
Clonal Evolution
Flow Cytometry
next generation sequencing
aCGH
solid tumors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00002/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00002/full

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