Generation and characterization of anti-AA amyloid-specific monoclonal antibodies

Generation and characterization of anti-AA amyloid-specific monoclonal antibodies

AA amyloidosis results from the pathologic deposition in the kidneys and other organs of fibrils composed of N-terminal fragments of serum amyloid A protein (SAA). Given that there are only limited means to visualize these deposits, we have developed a series of mAbs, 2A4, 7D8, and 8G9, that bind sp...

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Bibliographic Details
Main Authors: Jonathan S Wall, Stephen J Kennel, Tina eRichey, Amy eAllen, Alan eStuckey, Deborah T Weiss, Sallie D Macy, Robin eBarbour, Peter eSeubert, Alan eSolomon, Dale eSchenk
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-08-01
Series:Frontiers in Immunology
Subjects:
Immunotherapy
monoclonal antibodies
AA amyloidosis
radioimmunoimaging
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00032/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00032/full

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