Combination Treatment of OSI-906 with Aurora B Inhibitor Reduces Cell Viability via Cyclin B1 Degradation-Induced Mitotic Slippage

Combination Treatment of OSI-906 with Aurora B Inhibitor Reduces Cell Viability via Cyclin B1 Degradation-Induced Mitotic Slippage

Insulin-like growth factor 1 receptor (IGF1R), a receptor-type tyrosine kinase, transduces signals related to cell proliferation, survival, and differentiation. We recently reported that OSI-906, an IGF1R inhibitor, in combination with the Aurora B inhibitor ZM447439 suppresses cell proliferation. H...

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Bibliographic Details
Main Authors: Yuki Ikeda, Ryuji Yasutake, Ryuzaburo Yuki, Youhei Saito, Yuji Nakayama
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
linsitinib
OSI-906
ZM447439
IGF1R
Aurora B
M phase
Online Access:https://www.mdpi.com/1422-0067/22/11/5706

Internet

https://www.mdpi.com/1422-0067/22/11/5706

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