Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank

Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank

Background: The three main alleles of the APOE gene (ε4, ε3 and ε2) carry differential risks for conditions including Alzheimer's disease (AD) and cardiovascular disease. Due to their clinical significance, we explored disease associations of the APOE genotypes using a hypothesis-free, data-dri...

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Bibliographic Details
Main Authors: Amanda L. Lumsden, Anwar Mulugeta, Ang Zhou, Elina Hyppönen
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:EBioMedicine
Subjects:
Phenome-wide association
PheWAS
APOE
Apolipoprotein E
Disease risk
Biomarkers
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420303303

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http://www.sciencedirect.com/science/article/pii/S2352396420303303

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