The Effect of Substituted Benzene-Sulfonamides and Clinically Licensed Drugs on the Catalytic Activity of CynT2, a Carbonic Anhydrase Crucial for <i>Escherichia coli </i>Life Cycle

The Effect of Substituted Benzene-Sulfonamides and Clinically Licensed Drugs on the Catalytic Activity of CynT2, a Carbonic Anhydrase Crucial for <i>Escherichia coli </i>Life Cycle

Proteins are relevant antimicrobial drug targets, and among them, enzymes represent a significant group, since most of them catalyze reactions essential for supporting the central metabolism, or are necessary for the pathogen vitality. Genomic exploration of pathogenic and non-pathogenic microorgani...

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Bibliographic Details
Main Authors: Sonia Del Prete, Viviana De Luca, Silvia Bua, Alessio Nocentini, Vincenzo Carginale, Claudiu T. Supuran, Clemente Capasso
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
carbonic anhydrase
sulfonamides
inhibitors
antibacterials
<i>Escherichia coli</i>
stopped-flow assay
Online Access:https://www.mdpi.com/1422-0067/21/11/4175

Internet

https://www.mdpi.com/1422-0067/21/11/4175

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