Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia

Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia

Abstract Background Monozygotic twins are valuable in assessing the genetic vs environmental contribution to diseases. In the era of complete genome sequences, they allow identification of mutational mechanisms and specific genes and pathways that offer predisposition to the development of complex d...

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Bibliographic Details
Main Authors: C. A. Castellani, M. G. Melka, J. L. Gui, A. J. Gallo, R. L. O’Reilly, S. M. Singh
Format: Article
Language:English
Published: Wiley 2017-11-01
Series:Clinical and Translational Medicine
Subjects:
Schizophrenia
Whole genome sequencing
Monozygotic twins
Genome variation
Somatic mutation
Threshold model
Online Access:http://link.springer.com/article/10.1186/s40169-017-0174-1

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http://link.springer.com/article/10.1186/s40169-017-0174-1

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