High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma

High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma

Glioblastoma (GBM), the deadliest form of brain cancer, presents long-standing problems due to its localization. Chimeric antigen receptor (CAR) T cell immunotherapy has emerged as a powerful strategy to treat cancer. IL-13-receptor-α2 (IL13Rα2), present in over 75% of GBMs, has been recognized as a...

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Bibliographic Details
Main Authors: Gloria B. Kim, Virginia Aragon-Sanabria, Lauren Randolph, Hali Jiang, Joshua A. Reynolds, Becky S. Webb, Achuthamangalam Madhankumar, Xiaojun Lian, James R. Connor, Jian Yang, Cheng Dong
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2020-09-01
Series:Bioactive Materials
Subjects:
Glioblastoma
T cells
Nanoparticles
Targeted drug delivery
Citrate polymers
Fluorescence
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X20300712

Internet

http://www.sciencedirect.com/science/article/pii/S2452199X20300712

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