A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations

A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations

The identification of recurrent human leukocyte antigen (HLA) neoepitopes driving T cell responses against tumors poses a significant bottleneck in the development of approaches for precision cancer therapeutics. Here, we employ a bioinformatics method, Prediction of T Cell Epitopes for Cancer Thera...

Full description

Bibliographic Details
Main Authors: Jugmohit S. Toor, Arjun A. Rao, Andrew C. McShan, Mark Yarmarkovich, Santrupti Nerli, Karissa Yamaguchi, Ada A. Madejska, Son Nguyen, Sarvind Tripathi, John M. Maris, Sofie R. Salama, David Haussler, Nikolaos G. Sgourakis
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
neoepitopes
MHC class I
human leukocyte antigens
structural biology
computational biology
cancer
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00099/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00099/full

Similar Items