Effect of mannitol on the pharmacokinetics of amikacin in wistar rats

Effect of mannitol on the pharmacokinetics of amikacin in wistar rats

The study analyzed the effect of mannitol on the pharmacokinetics (PK) of amikacin. Adult Wistar rats were treated as follows: Group 1 (G1) received mannitol for three days, Group 2 (G2) received mannitol plus 10 mg/kg of amikacin simultaneously, and Group 3 only amikacin. The PK study was conducted...

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Bibliographic Details
Main Authors: Hugo Juárez Olguín, Miriam Carrasco Portugal, Janett Flores Pérez, Angélica Camacho Vieyra, Carmen Flores Pérez, Alfonso Alfaro Rodríguez
Format: Article
Language:English
Published: Instituto de Tecnologia do Paraná (Tecpar) 2009-08-01
Series:Brazilian Archives of Biology and Technology
Subjects:
Pharmacokinetics
interactions
amikacin
mannitol
antibiotics
diuretics
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000400006

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000400006

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