Inhibition of MEK1/2 and GSK3 (2i system) affects blastocyst quality and early differentiation of porcine parthenotes

Inhibition of both MEK1/2 and glycogen synthase kinase-3 (GSK3; 2i system) facilitates the maintenance of naïve stemness for embryonic stem cells in various mammalian species. However, the effect of the inhibition of the 2i system on porcine early embryogenesis is unknown. We investigated the effect...

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Bibliographic Details
Main Authors: Jeongwoo Kwon, Ying-Hua Li, Yu-Jin Jo, YoungJin Oh, Suk Namgoong, Nam-Hyung Kim
Format: Article
Language:English
Published: PeerJ Inc. 2019-01-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/5840.pdf