Molecular Docking and Molecular Dynamics Studies on Selective Synthesis of α-Amyrin and β-Amyrin by Oxidosqualene Cyclases from <i>Ilex Asprella</i>

Molecular Docking and Molecular Dynamics Studies on Selective Synthesis of α-Amyrin and β-Amyrin by Oxidosqualene Cyclases from <i>Ilex Asprella</i>

Amyrins are the immediate precursors of many pharmaceutically important pentacyclic triterpenoids. Although various amyrin synthases have been identified, little is known about the relationship between protein structures and the constituent and content of the products. IaAS1 and IaAS2 identified fro...

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Bibliographic Details
Main Authors: Zhixue Wu, Hui Xu, Meiling Wang, Ruoting Zhan, Weiwen Chen, Ren Zhang, Zaoyuan Kuang, Fengxue Zhang, Kui Wang, Jiangyong Gu
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
oxidosqualene cyclase
amyrin
selective synthesis
molecular modeling
residue-product interaction
Online Access:https://www.mdpi.com/1422-0067/20/14/3469

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https://www.mdpi.com/1422-0067/20/14/3469

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