Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis

Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis

Beta-2 microglobulin (beta2m) is an essential component of the major histocompatibility complex (MHC) class I proteins and in the nervous system beta2m is predominantly expressed in motor neurons. As beta2m can promote nerve regeneration, we investigated its potential role in amyotrophic lateral scl...

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Bibliographic Details
Main Authors: Kim A Staats, Susann eSchonefeldt, Marieke eVan Rillaer, Annelies eVan Hoecke, Philip eVan Damme, Wim eRobberecht, Adrian eListon, Ludo eVan Den Bosch
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Major Histocompatibility Complex
Motor Neurons
Nerve Regeneration
Neurodegenerative Diseases
neurodegeneration
Amyotrophic lateral sclerosis (ALS)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00249/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00249/full

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