Correlation between the results of in vitro and in vivo chromosomal damage tests in consideration of exposure levels of test chemicals

Correlation between the results of in vitro and in vivo chromosomal damage tests in consideration of exposure levels of test chemicals

Abstract Introduction We examined the correlation between the results of in vitro and in vivo chromosomal damage tests by using in-house data of 18 pharmaceutical candidates that showed positive results in the in vitro chromosomal aberration or micronucleus test using CHL/IU cells, and quantitativel...

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Bibliographic Details
Main Authors: Eiji Yamamura, Chinami Aruga, Shigeharu Muto, Nobuyuki Baba, Yoshifumi Uno
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Genes and Environment
Subjects:
Genotoxicity
In vitro-in vivo correlation
Chromosomal damage
Exposure level
Online Access:http://link.springer.com/article/10.1186/s41021-018-0094-3

Internet

http://link.springer.com/article/10.1186/s41021-018-0094-3

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