3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors Enhance Cytokine-mediated Induction of Nitric Oxide Synthesis in Vascular Smooth Muscle Cells

3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors Enhance Cytokine-mediated Induction of Nitric Oxide Synthesis in Vascular Smooth Muscle Cells

We investigated the effects of by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors, cerivastatin and fluvastatin, on the induction of nitric oxide (NO) production in vascular smooth muscle cells ( VSMC) stimulated by interleukin-1β (1L-1) or in combination with interferon-γ (IFN). IL-1 acti...

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Bibliographic Details
Main Authors: Hattori Yoshiyuki, Nakanishi Nobuo, Suzuki Manabu, Yoshida Mika, Kasai Kikuo
Format: Article
Language:English
Published: De Gruyter 2002-02-01
Series:Pteridines
Subjects:
statin
nitric oxide
tetrahydrobiopterin
vascular smooth muscle cell
Online Access:https://doi.org/10.1515/pteridines.2002.13.1.26

Internet

https://doi.org/10.1515/pteridines.2002.13.1.26

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