A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice

A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in methyl-CpG-binding protein-2 (MECP2), a transcriptional regulator of many genes, including brain-derived neurotrophic factor (BDNF). BDNF levels are reduced in RTT autopsy brains and in multiple brain areas of Mecp2-deficien...

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Bibliographic Details
Main Authors: Wei Li, Alba Bellot-Saez, Mary L. Phillips, Tao Yang, Frank M. Longo, Lucas Pozzo-Miller
Format: Article
Language:English
Published: The Company of Biologists 2017-07-01
Series:Disease Models & Mechanisms
Subjects:
BDNF
LM22A-4
MeCP2
LTP
Voltage-sensitive dye imaging
Ca2+ imaging
Object location memory
CA1 pyramidal neuron
Online Access:http://dmm.biologists.org/content/10/7/837

Internet

http://dmm.biologists.org/content/10/7/837

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