SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.

SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.

SIRT2 belongs to a highly conserved family of NAD+-dependent deacylases, consisting of seven members (SIRT1-SIRT7), which vary in subcellular localizations and have substrates ranging from histones to transcription factors and enzymes. Recently SIRT2 was revealed to play an important role in inflamm...

Full description

Bibliographic Details
Main Authors: Giuseppe Lo Sasso, Keir Joe Menzies, Adrienne Mottis, Alessandra Piersigilli, Alessia Perino, Hiroyasu Yamamoto, Kristina Schoonjans, Johan Auwerx
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4114785?pdf=render

Internet

http://europepmc.org/articles/PMC4114785?pdf=render

Similar Items