Frataxin Deficiency Leads to Reduced Expression and Impaired Translocation of NF-E2-Related Factor (Nrf2) in Cultured Motor Neurons

Frataxin Deficiency Leads to Reduced Expression and Impaired Translocation of NF-E2-Related Factor (Nrf2) in Cultured Motor Neurons

Oxidative stress has been implicated in the pathogenesis of Friedreich’s Ataxia (FRDA), a neurodegenerative disease caused by the decreased expression of frataxin, a mitochondrial protein responsible of iron homeostasis. Under conditions of oxidative stress, the activation of the transcription facto...

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Bibliographic Details
Main Authors: Enrico Bertini, Barbara Carletti, Sara Petrillo, Emanuela Piermarini, Chiara Priori, Lorena Travaglini, Stefania Petrini, Valentina D'Oria, Fiorella Piemonte
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:International Journal of Molecular Sciences
Subjects:
FRDA
frataxin
Nrf2
GSSG
oxidative stress
NSC34 neurons
Online Access:http://www.mdpi.com/1422-0067/14/4/7853

Internet

http://www.mdpi.com/1422-0067/14/4/7853

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