How the Proximal Pocket May Influence the Enantiospecificities of Chloroperoxidase-Catalyzed Epoxidations of Olefins

How the Proximal Pocket May Influence the Enantiospecificities of Chloroperoxidase-Catalyzed Epoxidations of Olefins

Chloroperoxidase-catalyzed enantiospecific epoxidations of olefins are of significant biotechnological interest. Typical enantiomeric excesses are in the range of 66%–97% and translate into free energy differences on the order of 1 kcal/mol. These differences are generally attributed to the effect o...

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Bibliographic Details
Main Authors: Alexander N. Morozov, David C. Chatfield
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:International Journal of Molecular Sciences
Subjects:
heme-thiolate enzymes
chloroperoxidase
cytochrome P450
Compound I
proximal pocket
hydrogen bonding
helix dipole
catalytic reactivity
epoxidation
density functional theory
Online Access:http://www.mdpi.com/1422-0067/17/8/1297

Internet

http://www.mdpi.com/1422-0067/17/8/1297

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