MLPA is a practical and complementary alternative to CMA for diagnostic testing in patients with autism spectrum disorders and identifying new candidate CNVs associated with autism

MLPA is a practical and complementary alternative to CMA for diagnostic testing in patients with autism spectrum disorders and identifying new candidate CNVs associated with autism

Background Autism spectrum disorder (ASD) is a complex heterogeneous developmental disease with a significant genetic background that is frequently caused by rare copy number variants (CNVs). Microarray-based whole-genome approaches for CNV detection are widely accepted. However, the clinical signif...

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Bibliographic Details
Main Authors: Pavlina Capkova, Josef Srovnal, Zuzana Capkova, Katerina Staffova, Vera Becvarova, Marie Trkova, Katerina Adamova, Alena Santava, Vaclava Curtisova, Marian Hajduch, Martin Prochazka
Format: Article
Language:English
Published: PeerJ Inc. 2019-01-01
Series:PeerJ
Subjects:
Autism spectrum disorders
Copy number variants
Multiplex ligation-dependent probe amplification
DOCK8
Chromosomal microarray analysis
Online Access:https://peerj.com/articles/6183.pdf

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https://peerj.com/articles/6183.pdf

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