Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome

Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome

Adult rats treated concomitantly with insulin and human chorionic gonadotropin exhibit endocrine, metabolic, and reproductive abnormalities that are very similar to those observed in polycystic ovary syndrome (PCOS) patients. In this study, we used this rat model to assess the effects of metformin o...

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Bibliographic Details
Main Authors: Yuehui Zhang, Min Hu, Fanci Meng, Xiaoyan Sun, Hongfei Xu, Jiao Zhang, Peng Cui, Njomeza Morina, Xin Li, Wei Li, Xiao-Ke Wu, Mats Brännström, Ruijin Shao, Håkan Billig
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:EBioMedicine
Subjects:
Metformin
Hyperandrogenism
Insulin resistance
Molecular mechanism
PCOS
Rat uterus
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417301196

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http://www.sciencedirect.com/science/article/pii/S2352396417301196

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