Psychosine induces the dephosphorylation of neurofilaments by deregulation of PP1 and PP2A phosphatases

Psychosine induces the dephosphorylation of neurofilaments by deregulation of PP1 and PP2A phosphatases

Patients with Krabbe disease, a genetic demyelinating syndrome caused by deficiency of galactosyl-ceramidase and the resulting accumulation of galactosyl-sphingolipids, develop signs of a dying-back axonopathy compounded by a deficiency of large-caliber axons. Here, we show that axonal caliber in Tw...

Full description

Bibliographic Details
Main Authors: Ludovico Cantuti-Castelvetri, Hongling Zhu, Maria I. Givogri, Robstein L. Chidavaenzi, Aurora Lopez-Rosas, Ernesto R. Bongarzone
Format: Article
Language:English
Published: Elsevier 2012-05-01
Series:Neurobiology of Disease
Subjects:
Leukodystrophies
Twitcher
Krabbe disease
Neurofilament
Myelin
Dying-back pathology
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611200037X

Internet

http://www.sciencedirect.com/science/article/pii/S096999611200037X

Similar Items