Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery

Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery

Extracellular vesicles (EVs) hold great potential as novel systems for nucleic acid delivery due to their natural composition. Our goal was to load EVs with microRNA that are synthesized by the cells that produce the EVs. HEK293T cells were engineered to produce EVs expressing a lysosomal associated...

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Bibliographic Details
Main Authors: Dhruvitkumar S. Sutaria, Jinmai Jiang, Ola A. Elgamal, Steven M. Pomeroy, Mohamed Badawi, Xiaohua Zhu, Ryan Pavlovicz, Ana Clara P. Azevedo-Pouly, Jeffrey Chalmers, Chenglong Li, Mitch A. Phelps, Thomas D. Schmittgen
Format: Article
Language:English
Published: Taylor & Francis Group 2017-12-01
Series:Journal of Extracellular Vesicles
Subjects:
Exosomes
microRNA mimic
HIV-1 TAR RNA
TAT peptide
hepatocellular cancer
small hairpin RNA
shRNA
Online Access:http://dx.doi.org/10.1080/20013078.2017.1333882

Internet

http://dx.doi.org/10.1080/20013078.2017.1333882

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