Placement of leucine zipper motifs at the carboxyl terminus of HIV-1 protease significantly reduces virion production.

Placement of leucine zipper motifs at the carboxyl terminus of HIV-1 protease significantly reduces virion production.

Natural HIV-1 protease (PR) is homodimeric. Some researchers believe that interactions between HIV-1 Gag-Pol molecules trigger the activation of embedded PR (which mediates Gag and Gag-Pol cleavage), and that Gag-Pol assembly domains outside of PR may contribute to PR activation by influencing PR di...

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Bibliographic Details
Main Authors: Yen-Yu Pan, Shiu-Mei Wang, Kuo-Jung Huang, Chien-Cheng Chiang, Chin-Tien Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3291649?pdf=render

Internet

http://europepmc.org/articles/PMC3291649?pdf=render

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