Respiratory Syncytial Virus Infection of Human Lung Fibroblasts Induces a Hyaluronan-Enriched Extracellular Matrix That Binds Mast Cells and Enhances Expression of Mast Cell Proteases

Respiratory Syncytial Virus Infection of Human Lung Fibroblasts Induces a Hyaluronan-Enriched Extracellular Matrix That Binds Mast Cells and Enhances Expression of Mast Cell Proteases

Human lung fibroblasts (HLFs) treated with the viral mimetic polyinosine-polycytidylic acid (poly I:C) form an extracellular matrix (ECM) enriched in hyaluronan (HA) that avidly binds monocytes and lymphocytes. Mast cells are important innate immune cells in both asthma and acute respiratory infecti...

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Bibliographic Details
Main Authors: Stephen R. Reeves, Kaitlyn A. Barrow, Lucille M. Rich, Maria P. White, Nicholas J. Shubin, Christina K. Chan, Inkyung Kang, Steven F. Ziegler, Adrian M. Piliponsky, Thomas N. Wight, Jason S. Debley
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
airway inflammation
airway remodeling
extracellular matrix
human lung fibroblasts
hyaluronan
mast cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03159/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03159/full

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