Alterations in ECM signature underscore multiple sub-phenotypes of intervertebral disc degeneration

The intervertebral disc is a specialized connective tissue critical for absorption of mechanical loads and providing flexibility to the spinal column. The disc ECM is complex and plays a vital role in imparting tissue its biomechanical function. The central NP is primarily composed of large aggregat...

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Bibliographic Details
Main Authors: Takashi Ohnishi, Emanuel J. Novais, Makarand V. Risbud
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Matrix Biology Plus
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S259002852030017X