Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5

Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5

The most potent cell wall-derived inflammatory toxins (“pathogenicity factors”) of Gram-negative and -positive bacteria are lipopolysaccharides (LPS) (endotoxins) and lipoproteins (LP), respectively. Despite the fact that the former signals via toll-like receptor 4 (TLR4) and the latter via TLR2, th...

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Bibliographic Details
Main Authors: Lena Heinbockel, Günther Weindl, Guillermo Martinez-de-Tejada, Wilmar Correa, Susana Sanchez-Gomez, Sergio Bárcena-Varela, Torsten Goldmann, Patrick Garidel, Thomas Gutsmann, Klaus Brandenburg
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
antimicrobial peptides
Pep19-2.5
sepsis
intracellular LPS signaling
endotoxin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01704/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01704/full

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