Canine REIC/Dkk-3 interacts with SGTA and restores androgen receptor signalling in androgen-independent prostate cancer cell lines

Canine REIC/Dkk-3 interacts with SGTA and restores androgen receptor signalling in androgen-independent prostate cancer cell lines

Abstract Background The pathological condition of canine prostate cancer resembles that of human androgen-independent prostate cancer. Both canine and human androgen receptor (AR) signalling are inhibited by overexpression of the dimerized co-chaperone small glutamine-rich tetratricopeptide repeat-c...

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Bibliographic Details
Main Authors: Yuiko Kato, Kazuhiko Ochiai, Shota Kawakami, Nobuhiro Nakao, Daigo Azakami, Makoto Bonkobara, Masaki Michishita, Masami Morimatsu, Masami Watanabe, Toshinori Omi
Format: Article
Language:English
Published: BMC 2017-06-01
Series:BMC Veterinary Research
Subjects:
Androgen receptor (AR) signalling
Canine
Prostate cancer
Reduced expression in immortalised cells (REIC/Dkk-3)
Small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA)
Online Access:http://link.springer.com/article/10.1186/s12917-017-1094-4

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http://link.springer.com/article/10.1186/s12917-017-1094-4

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