Regulatory role of voltage-gated sodium channel β subunits in sensory neurons

Regulatory role of voltage-gated sodium channel β subunits in sensory neurons

Voltage-gated Na+ channels are transmembrane-bound proteins incorporating aqueous conduction pores that are highly selective for Na+. The opening of these channels results in the rapid influx of Na+ ions that depolarize the cell and drive the rapid upstroke of nerve and muscle action potentials. Whi...

Full description

Bibliographic Details
Main Authors:	Mohamed eChahine, Michael E O'Leary
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2011-11-01
Series:	Frontiers in Pharmacology
Subjects:	Pain Peripheral Nervous System beta subunit voltage-gated sodium channel
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00070/full

Similar Items

Recent advances in voltage-gated sodium channels, their pharmacology and related diseases
by: Jean-François eDesaphy, et al.
Published: (2013-04-01)

β1- and β3- voltage-gated sodium channel subunits modulate cell surface expression and glycosylation of Nav1.7 in HEK293 cells
by: Cedric James Laedermann, et al.
Published: (2013-08-01)

On the multiple roles of the voltage gated sodium channel β1 subunit in genetic diseases
by: Debora eBaroni, et al.
Published: (2015-05-01)

Biochemical techniques for the study of voltage-gated sodium channel auxiliary subunits
by: Molinarolo, Steven
Published: (2018)

Na+ channel β subunits: Overachievers of the ion channel family
by: William J Brackenbury, et al.
Published: (2011-09-01)

Contribution of voltage-gated sodium channel β-subunits to cervical cancer cells metastatic behavior
by: Ana Laura Sanchez-Sandoval, et al.
Published: (2019-02-01)

Effect of Oxaliplatin on Voltage-Gated Sodium Channels in Peripheral Neuropathic Pain
by: Woojin Kim
Published: (2020-06-01)

Neurotoxins and their binding areas on voltage-gated sodium channels
by: Marijke eStevens, et al.
Published: (2011-11-01)

VOLTAGE-GATED SODIUM CHANNELS AND CANCER: IS EXCITABILITY THEIR PRIMARY ROLE?
by: Sébastien eRoger, et al.
Published: (2015-07-01)

The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms
by: Jeffrey Lopez-Rojas, et al.
Published: (2017-04-01)

Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies
by: Eleonora eSavio Galimberti, et al.
Published: (2012-07-01)

Elevated neuronal excitability due to modulation of the voltage-gated sodium channel Nav1.6 by Aβ1-42
by: Xi eWang, et al.
Published: (2016-03-01)

Marine Toxins That Target Voltage-gated Sodium Channels
by: Robert J. French, et al.
Published: (2006-04-01)

Regulation of Cough by Voltage-Gated Sodium Channels in Airway Sensory Nerves
by: Svajdova S, et al.
Published: (2018-12-01)

Cell-Adhesion Properties of β-Subunits in the Regulation of Cardiomyocyte Sodium Channels
by: Samantha C Salvage, et al.
Published: (2020-07-01)

Action of Clathrodin and Analogues on Voltage-Gated Sodium Channels
by: Steve Peigneur, et al.
Published: (2014-04-01)

Calmodulin Interactions with Voltage-Gated Sodium Channels
by: Xin Wu, et al.
Published: (2021-09-01)

Eukaryotic Voltage-Gated Sodium Channels: On Their Origins, Asymmetries, Losses, Diversification and Adaptations
by: Julia E. Fux, et al.
Published: (2018-11-01)

Correlation of the electrophysiological profiles and sodium channel transcripts of individual rat dorsal root ganglia neurons
by: Olivier eTheriault, et al.
Published: (2014-09-01)

Molecular Determinants of Brevetoxin Binding to Voltage-Gated Sodium Channels
by: Keiichi Konoki, et al.
Published: (2019-09-01)

Voltage-Gated Sodium Channels in Neocortical Pyramidal Neurons Display Cole-Moore Activation Kinetics
by: Mara Almog, et al.
Published: (2018-06-01)

The β2-Subunit of Voltage-Gated Calcium Channels Regulates Cardiomyocyte Hypertrophy
by: Simone Pickel, et al.
Published: (2021-07-01)

Dehydrocrenatidine Inhibits Voltage-Gated Sodium Channels and Ameliorates Mechanic Allodia in a Rat Model of Neuropathic Pain
by: Fang Zhao, et al.
Published: (2019-04-01)

Trafficking and Function of the Voltage-Gated Sodium Channel β2 Subunit
by: Eric Cortada, et al.
Published: (2019-10-01)

Biophysics, Pathophysiology and Pharmacology of Ion Channel Gating Pores
by: Adrien eMoreau, et al.
Published: (2014-04-01)

Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor
by: Kanna Adachi, et al.
Published: (2019-12-01)

Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice
by: Akito eNakao, et al.
Published: (2015-06-01)

Domain–domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel
by: Mark A Zaydman, et al.
Published: (2014-12-01)

Recent advances in voltage-gated sodium channels, their pharmacology and related diseases
by: Mohamed eChahine, et al.
Published: (2016-02-01)

Expression of voltage-gated sodium channel in primary tumors and corresponding metastases in the Copenhagen rat model of prostate cancer
by: Şenay Yıldırım
Published: (2013-12-01)

Voltage-gated sodium channel inhibitor reduces atherosclerosis by modulating monocyte/macrophage subsets and suppressing macrophage proliferation
by: Haiying Sun, et al.
Published: (2019-12-01)

Cannabidiol interactions with voltage-gated sodium channels
by: Lily Goodyer Sait, et al.
Published: (2020-10-01)

Voltage-Gated Sodium Channel β1/β1B Subunits Regulate Cardiac Physiology and Pathophysiology
by: Nnamdi Edokobi, et al.
Published: (2018-04-01)

Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes.
by: Cédric James Laedermann, et al.
Published: (2015-11-01)

Biophysical Properties of Somatic and Axonal Voltage-Gated Sodium Channels in Midbrain Dopaminergic Neurons
by: Jun Yang, et al.
Published: (2019-07-01)

GATING OF THE SENSORY NEURONAL VOLTAGE-GATED SODIUM CHANNEL NAv1.7: ANALYSIS OF THE ROLE OF D3 AND D4 / S4-S5 LINKERS IN TRANSITION TO AN INACTIVATED STATE
by: Jarecki, Brian W.
Published: (2010)

Role of High Voltage-Gated Ca<sup>2+</sup> Channel Subunits in Pancreatic β-Cell Insulin Release. From Structure to Function
by: Petronel Tuluc, et al.
Published: (2021-08-01)

In Vivo Evidence for Voltage-Gated Sodium Channel Expression in Carcinomas and Potentiation of Metastasis
by: Mustafa B. A. Djamgoz, et al.
Published: (2019-10-01)

1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain
by: Yuan Zhou, et al.
Published: (2020-05-01)

Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA
by: Rocio K. Finol-Urdaneta, et al.
Published: (2019-08-01)