Induction and maintenance of protective CD8+ T cells against malaria liver stages: implications for vaccine development

CD8+ T cells against malaria liver stages represent a major protective immune mechanism against infection. Following induction in the peripheral lymph nodes by dendritic cells (DCs), these CD8+ T cells migrate to the liver and eliminate parasite infected hepatocytes. The processing and presentation...

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Bibliographic Details
Main Authors: Sze-Wah Tse, Andrea J Radtke, Fidel Zavala
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2011-08-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000900022&lng=en&tlng=en