NETosing neutrophils activate complement both on their own NETs and bacteria via alternative and non-alternative pathways

NETosing neutrophils activate complement both on their own NETs and bacteria via alternative and non-alternative pathways

Neutrophils deposit antimicrobial proteins such as myeloperoxidase and proteases on chromatin, which they release as neutrophil extracellular traps (NETs). Neutrophils also carry key components of the complement alternative pathway (AP) such as properdin or complement factor P (CFP), complement fact...

Full description

Bibliographic Details
Main Authors: Joshua eYuen, Fred G. Pluthero, David N. Douda, Magdalena eRiedl, Ahmed eCherry, Marina eUlanova, Walter H.A. Kahr, Nades ePalaniyar, Christoph eLicht
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Immunology
Subjects:
Properdin
Pseudomonas aeruginosa
complement system
neutrophil extracellular traps
alternative pathway
NEtosis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00137/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00137/full

Similar Items