Controlled breast cancer microarrays for the deconvolution of cellular multilayering and density effects upon drug responses.

Increasing evidence shows that the cancer microenvironment affects both tumorigenesis and the response of cancer to drug treatment. Therefore in vitro models that selectively reflect characteristics of the in vivo environment are greatly needed. Current methods allow us to screen the effect of extri...

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Bibliographic Details
Main Authors: Maria Håkanson, Stefan Kobel, Matthias P Lutolf, Marcus Textor, Edna Cukierman, Mirren Charnley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3387021?pdf=render