Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease

Polycystic kidney disease (PKD) is characterized by slow expansion of fluid-filled cysts derived from tubules within the kidney. Cystic expansion results in injury to surrounding parenchyma and leads to inflammation, scarring and ultimately loss of renal function. Macrophages are a key element in th...

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Bibliographic Details
Main Authors: Jacqueline D. Peda, Sally M. Salah, Darren P. Wallace, Patrick E. Fields, Connor J. Grantham, Timothy A. Fields, Katherine I. Swenson-Fields
Format: Article
Language:English
Published: The Company of Biologists 2016-09-01
Series:Disease Models & Mechanisms
Subjects:
PKD
Online Access:http://dmm.biologists.org/content/9/9/1051