Role of the immunosuppressive microenvironment in immunotherapy

Immunotherapy is reshaping cancer treatment paradigms; however, response rates to immune therapies are low and depend on the host's pre-existing antitumor immunity. The tumor microenvironment is comprised of malignant cells, stroma, and extracellular molecules and can hinder immune control of t...

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Main Authors:	Garth W. Tormoen, MD, PhD, Marka R. Crittenden, MD, PhD, Michael J. Gough, PhD
Format:	Article
Language:	English
Published:	Elsevier 2018-10-01
Series:	Advances in Radiation Oncology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2452109418301507

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spelling	doaj-7bc68c29409c4958b3fd022c9555f0a52020-11-24T21:18:00ZengElsevierAdvances in Radiation Oncology2452-10942018-10-0134520526Role of the immunosuppressive microenvironment in immunotherapyGarth W. Tormoen, MD, PhD0Marka R. Crittenden, MD, PhD1Michael J. Gough, PhD2Department of Radiation Medicine, Oregon Health & Science University, Portland, Oregon; Corresponding author. Oregon Health and Science University, Department of Radiation Medicine, 3181 SW Sam Jackson Parkway, Portland, OR 97239.Earl A. Chiles Research Institute, Providence Portland Medical Center, Portland, Oregon; The Oregon Clinic, Portland, OregonEarl A. Chiles Research Institute, Providence Portland Medical Center, Portland, OregonImmunotherapy is reshaping cancer treatment paradigms; however, response rates to immune therapies are low and depend on the host's pre-existing antitumor immunity. The tumor microenvironment is comprised of malignant cells, stroma, and extracellular molecules and can hinder immune control of tumors. Herein, we review how anti-tumor immune responses are formed and how tumors avoid immune destruction. We also outline potential therapeutic targets in the immunosuppressive tumor microenvironment to promote immune control of tumors.http://www.sciencedirect.com/science/article/pii/S2452109418301507
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Garth W. Tormoen, MD, PhD Marka R. Crittenden, MD, PhD Michael J. Gough, PhD
spellingShingle	Garth W. Tormoen, MD, PhD Marka R. Crittenden, MD, PhD Michael J. Gough, PhD Role of the immunosuppressive microenvironment in immunotherapy Advances in Radiation Oncology
author_facet	Garth W. Tormoen, MD, PhD Marka R. Crittenden, MD, PhD Michael J. Gough, PhD
author_sort	Garth W. Tormoen, MD, PhD
title	Role of the immunosuppressive microenvironment in immunotherapy
title_short	Role of the immunosuppressive microenvironment in immunotherapy
title_full	Role of the immunosuppressive microenvironment in immunotherapy
title_fullStr	Role of the immunosuppressive microenvironment in immunotherapy
title_full_unstemmed	Role of the immunosuppressive microenvironment in immunotherapy
title_sort	role of the immunosuppressive microenvironment in immunotherapy
publisher	Elsevier
series	Advances in Radiation Oncology
issn	2452-1094
publishDate	2018-10-01
description	Immunotherapy is reshaping cancer treatment paradigms; however, response rates to immune therapies are low and depend on the host's pre-existing antitumor immunity. The tumor microenvironment is comprised of malignant cells, stroma, and extracellular molecules and can hinder immune control of tumors. Herein, we review how anti-tumor immune responses are formed and how tumors avoid immune destruction. We also outline potential therapeutic targets in the immunosuppressive tumor microenvironment to promote immune control of tumors.
url	http://www.sciencedirect.com/science/article/pii/S2452109418301507
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Role of the immunosuppressive microenvironment in immunotherapy

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